Nitrogen-containing dimeric nor-multiflorane triterpene from a Turraea sp.
Identifieur interne : 001012 ( Main/Exploration ); précédent : 001011; suivant : 001013Nitrogen-containing dimeric nor-multiflorane triterpene from a Turraea sp.
Auteurs : Vincent E. Rasamison [Madagascar] ; L Harinantenaina Rakotondraibe ; Carla Slebodnick ; Peggy J. Brodie ; Michel Ratsimbason ; Karen Tendyke ; Yongchun Shen ; Lucien M. Randrianjanaka ; David G I. KingstonSource :
- Organic letters [ 1523-7052 ] ; 2014.
Descripteurs français
- KwdFr :
- Antinéoplasiques d'origine végétale (), Antinéoplasiques d'origine végétale (isolement et purification), Antinéoplasiques d'origine végétale (pharmacologie), Antipaludiques (), Antipaludiques (isolement et purification), Antipaludiques (pharmacologie), Azote (), Chloroquine (pharmacologie), Concentration inhibitrice 50, Feuilles de plante (), Humains, Meliaceae (), Plasmodium falciparum (), Structure moléculaire, Tests de criblage d'agents antitumoraux, Triterpènes (), Triterpènes (isolement et purification), Triterpènes (pharmacologie).
- MESH :
- isolement et purification : Antinéoplasiques d'origine végétale, Antipaludiques, Triterpènes.
- pharmacologie : Antinéoplasiques d'origine végétale, Antipaludiques, Chloroquine, Triterpènes.
- Antinéoplasiques d'origine végétale, Antipaludiques, Azote, Concentration inhibitrice 50, Feuilles de plante, Humains, Meliaceae, Plasmodium falciparum, Structure moléculaire, Tests de criblage d'agents antitumoraux, Triterpènes.
English descriptors
- KwdEn :
- Antimalarials (chemistry), Antimalarials (isolation & purification), Antimalarials (pharmacology), Antineoplastic Agents, Phytogenic (chemistry), Antineoplastic Agents, Phytogenic (isolation & purification), Antineoplastic Agents, Phytogenic (pharmacology), Chloroquine (pharmacology), Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Meliaceae (chemistry), Molecular Structure, Nitrogen (chemistry), Plant Leaves (chemistry), Plasmodium falciparum (drug effects), Triterpenes (chemistry), Triterpenes (isolation & purification), Triterpenes (pharmacology).
- MESH :
- chemical , chemistry : Antimalarials, Antineoplastic Agents, Phytogenic, Nitrogen, Triterpenes.
- chemical , isolation & purification : Antimalarials, Antineoplastic Agents, Phytogenic, Triterpenes.
- chemical , pharmacology : Antimalarials, Antineoplastic Agents, Phytogenic, Chloroquine, Triterpenes.
- chemistry : Meliaceae, Plant Leaves.
- drug effects : Plasmodium falciparum.
- Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Molecular Structure.
Abstract
The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.
DOI: 10.1021/ol500775r
PubMed: 24773558
Affiliations:
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Le document en format XML
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Rasamison</name><affiliation wicri:level="1"><nlm:affiliation>Centre National d'Application des Recherches Pharmaceutiques B.P , 702, Antananarivo 101, Madagascar.</nlm:affiliation><country xml:lang="fr">Madagascar</country><wicri:regionArea>Centre National d'Application des Recherches Pharmaceutiques B.P , 702, Antananarivo 101</wicri:regionArea><wicri:noRegion>Antananarivo 101</wicri:noRegion></affiliation></author><author><name sortKey="Rakotondraibe, L Harinantenaina" sort="Rakotondraibe, L Harinantenaina" uniqKey="Rakotondraibe L" first="L Harinantenaina" last="Rakotondraibe">L Harinantenaina Rakotondraibe</name></author><author><name sortKey="Slebodnick, Carla" sort="Slebodnick, Carla" uniqKey="Slebodnick C" first="Carla" last="Slebodnick">Carla Slebodnick</name></author><author><name sortKey="Brodie, Peggy J" sort="Brodie, Peggy J" uniqKey="Brodie P" first="Peggy J" last="Brodie">Peggy J. 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Rasamison</name><affiliation wicri:level="1"><nlm:affiliation>Centre National d'Application des Recherches Pharmaceutiques B.P , 702, Antananarivo 101, Madagascar.</nlm:affiliation><country xml:lang="fr">Madagascar</country><wicri:regionArea>Centre National d'Application des Recherches Pharmaceutiques B.P , 702, Antananarivo 101</wicri:regionArea><wicri:noRegion>Antananarivo 101</wicri:noRegion></affiliation></author><author><name sortKey="Rakotondraibe, L Harinantenaina" sort="Rakotondraibe, L Harinantenaina" uniqKey="Rakotondraibe L" first="L Harinantenaina" last="Rakotondraibe">L Harinantenaina Rakotondraibe</name></author><author><name sortKey="Slebodnick, Carla" sort="Slebodnick, Carla" uniqKey="Slebodnick C" first="Carla" last="Slebodnick">Carla Slebodnick</name></author><author><name sortKey="Brodie, Peggy J" sort="Brodie, Peggy J" uniqKey="Brodie P" first="Peggy J" last="Brodie">Peggy J. Brodie</name></author><author><name sortKey="Ratsimbason, Michel" sort="Ratsimbason, Michel" uniqKey="Ratsimbason M" first="Michel" last="Ratsimbason">Michel Ratsimbason</name></author><author><name sortKey="Tendyke, Karen" sort="Tendyke, Karen" uniqKey="Tendyke K" first="Karen" last="Tendyke">Karen Tendyke</name></author><author><name sortKey="Shen, Yongchun" sort="Shen, Yongchun" uniqKey="Shen Y" first="Yongchun" last="Shen">Yongchun Shen</name></author><author><name sortKey="Randrianjanaka, Lucien M" sort="Randrianjanaka, Lucien M" uniqKey="Randrianjanaka L" first="Lucien M" last="Randrianjanaka">Lucien M. Randrianjanaka</name></author><author><name sortKey="Kingston, David G I" sort="Kingston, David G I" uniqKey="Kingston D" first="David G I" last="Kingston">David G I. Kingston</name></author></analytic><series><title level="j">Organic letters</title><idno type="eISSN">1523-7052</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (chemistry)</term><term>Antimalarials (isolation & purification)</term><term>Antimalarials (pharmacology)</term><term>Antineoplastic Agents, Phytogenic (chemistry)</term><term>Antineoplastic Agents, Phytogenic (isolation & purification)</term><term>Antineoplastic Agents, Phytogenic (pharmacology)</term><term>Chloroquine (pharmacology)</term><term>Drug Screening Assays, Antitumor</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Meliaceae (chemistry)</term><term>Molecular Structure</term><term>Nitrogen (chemistry)</term><term>Plant Leaves (chemistry)</term><term>Plasmodium falciparum (drug effects)</term><term>Triterpenes (chemistry)</term><term>Triterpenes (isolation & purification)</term><term>Triterpenes (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques d'origine végétale ()</term><term>Antinéoplasiques d'origine végétale (isolement et purification)</term><term>Antinéoplasiques d'origine végétale (pharmacologie)</term><term>Antipaludiques ()</term><term>Antipaludiques (isolement et purification)</term><term>Antipaludiques (pharmacologie)</term><term>Azote ()</term><term>Chloroquine (pharmacologie)</term><term>Concentration inhibitrice 50</term><term>Feuilles de plante ()</term><term>Humains</term><term>Meliaceae ()</term><term>Plasmodium falciparum ()</term><term>Structure moléculaire</term><term>Tests de criblage d'agents antitumoraux</term><term>Triterpènes ()</term><term>Triterpènes (isolement et purification)</term><term>Triterpènes (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antimalarials</term><term>Antineoplastic Agents, Phytogenic</term><term>Nitrogen</term><term>Triterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antimalarials</term><term>Antineoplastic Agents, Phytogenic</term><term>Triterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term><term>Antineoplastic Agents, Phytogenic</term><term>Chloroquine</term><term>Triterpenes</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Meliaceae</term><term>Plant Leaves</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antinéoplasiques d'origine végétale</term><term>Antipaludiques</term><term>Triterpènes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques d'origine végétale</term><term>Antipaludiques</term><term>Chloroquine</term><term>Triterpènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Screening Assays, Antitumor</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Molecular Structure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antinéoplasiques d'origine végétale</term><term>Antipaludiques</term><term>Azote</term><term>Concentration inhibitrice 50</term><term>Feuilles de plante</term><term>Humains</term><term>Meliaceae</term><term>Plasmodium falciparum</term><term>Structure moléculaire</term><term>Tests de criblage d'agents antitumoraux</term><term>Triterpènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC50 value of 16.4 μM. </div></front></TEI><affiliations><list><country><li>Madagascar</li></country></list><tree><noCountry><name sortKey="Brodie, Peggy J" sort="Brodie, Peggy J" uniqKey="Brodie P" first="Peggy J" last="Brodie">Peggy J. Brodie</name><name sortKey="Kingston, David G I" sort="Kingston, David G I" uniqKey="Kingston D" first="David G I" last="Kingston">David G I. Kingston</name><name sortKey="Rakotondraibe, L Harinantenaina" sort="Rakotondraibe, L Harinantenaina" uniqKey="Rakotondraibe L" first="L Harinantenaina" last="Rakotondraibe">L Harinantenaina Rakotondraibe</name><name sortKey="Randrianjanaka, Lucien M" sort="Randrianjanaka, Lucien M" uniqKey="Randrianjanaka L" first="Lucien M" last="Randrianjanaka">Lucien M. Randrianjanaka</name><name sortKey="Ratsimbason, Michel" sort="Ratsimbason, Michel" uniqKey="Ratsimbason M" first="Michel" last="Ratsimbason">Michel Ratsimbason</name><name sortKey="Shen, Yongchun" sort="Shen, Yongchun" uniqKey="Shen Y" first="Yongchun" last="Shen">Yongchun Shen</name><name sortKey="Slebodnick, Carla" sort="Slebodnick, Carla" uniqKey="Slebodnick C" first="Carla" last="Slebodnick">Carla Slebodnick</name><name sortKey="Tendyke, Karen" sort="Tendyke, Karen" uniqKey="Tendyke K" first="Karen" last="Tendyke">Karen Tendyke</name></noCountry><country name="Madagascar"><noRegion><name sortKey="Rasamison, Vincent E" sort="Rasamison, Vincent E" uniqKey="Rasamison V" first="Vincent E" last="Rasamison">Vincent E. Rasamison</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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